Insilco LOD

Notes

Selected 30 LSR and 30 FORTESSA files matched for panel1 and panel2 that:

• had an event count > 700000
• had 0 “bad”,“abnormal”, or “manual” annotatations

Within this set:

• randomly sub-sampled events 10 times per threshold, with requirement that number of events sampled be < %50 of total events

Failure rate by number of events sampled

Population specific variability

• Frequency Parent CV computed within a sample for each event threshold (10 replicates at 2k,10 replicates at 3k, etc)

Plots below - for each population

1. Boxplots of sample CVs at each event threshold
2. Number of events in lymph/pbmc vs sample CV
3. Histogram of number of events in lymph/pbmc
4. Boxplots of sample CVs for binned lymph/pbmc counts
5. Number of events in lymph/pbmc vs number of events in the population

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